IDEXX Catalyst SDMA 檢測

為什麼每次檢測CREATININE和 BUN 時,也必須檢測 SDMA

SDMA 因為 3 個關鍵特性而提供了更深入的發現

  • SDMA 是腎功能的生物標記物。
  • SDMA 最早在腎功能僅喪失25% 的時候就會升高。1–3
  • SDMA是腎功能特異性很高的指標,肌肉量、高齡、和疾病狀態等因素對SDMA的影響比較小。4,5

Read: How SDMA detects chronic kidney disease earlier

SDMA 是重要關鍵的幾種常見的情況

SDMA 升高而其他結果都正常
SDMA 檢測到 Bess 的慢性腎臟病 (CKD),讓治療更早開始。

Bess 顯示有一些中度牙周病,其他檢查參數皆在正常範圍內。瞭解為什麼在 SDMA 升高且其他因素看起來正常時要特別注意。 
閱讀案例研究。


診斷甲狀腺功能亢進患者時
SDMA 幫助患有甲狀腺功能亢進的貓 Zeke 偵測到 CKD。

由於 SDMA 不受肌肉質量變化的影響,因此 SDMA 比單獨使用肌酸酐和 BUN 診斷出更多甲狀腺功能亢進貓隻的 CKD。4,5閱讀案例研究瞭解更多詳情。關於甲狀腺功能亢進的貓和 IDEXX SDMA 檢測。


評估幼犬與幼貓的腎功能時

在幼犬中,IDEXX SDMA 檢測參考區間 (0–16 μg/dL) 已確立略高於成犬的參考區間 (0–14 μg/dL)。幼小患者參考區間的研究證實成貓的參考區間 0-14 µg/dL 也適用於幼貓。 

Assess kidney function of puppies and kittens using SDMA

更深入的發現

詳細瞭解為什麼 SDMA 是每次生化檢測時的必要的檢測項目呢? 

滑動即可查看我們的專有軟體和裝置。

注意:SDMA 是對稱二甲基精氨酸。

參考文獻

  1. Nabity MB, Lees GE, Boggess M, et al.Symmetric dimethylarginine assay validation, stability, and evaluation as a marker for early detection of chronic kidney disease in dogs.J Vet Intern Med.2015;29(4):1036-1044.
  2. Hall JA, Yerramilli M, Obare E, Yerramilli M, Jewell DE.Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in cats with chronic kidney disease.J Vet Intern Med.2014;28(6):1676-1683.
  3. Hall JA, Yerramilli M, Obare E, Yerramilli M, Almes K, Jewell DE.Serum concentrations of symmetric dimethylarginine and creatinine in dogs with naturally occurring chronic kidney disease.J Vet Intern Med.2016;30(3):794-802.
  4. Hall JA, Yerramilli M, Obare E, Yerramilli M, Yu S, Jewell DE.Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in healthy geriatric cats fed reduced protein foods enriched with fish oil, L-carnitine, and medium-chain triglycerides.Vet J. 2014;202(3):588–596.
  5. Hall JA, Yerramilli M, Obare E, Yerramilli M, Melendez LD, Jewell DE.Relationship between lean body mass and serum renal biomarkers in healthy dogs.J Vet Intern Med.2015;29(3):808-814.
  6. International Renal Interest Society.2015 IRIS CKD Staging Guidelines. www.iris-kidney.com/guidelines.Accessed May 9, 2018.
  7. Data on file at IDEXX Laboratories, Inc. Westbrook, Maine USA.
  8. Lulich JP, Osborne CA, O'Brien TD, Polzin DJ.Feline renal failure: questions, answers, questions.Compend Contin Educ Pract Vet.1992;14(2):127-153.
  9. Brown SA.Renal dysfunction in small animals.The Merck Veterinary Manual website. www.merckvetmanual.com/urinary_system/noninfectious_diseases_of_the_urinary_system_in_small_animals/renal_dysfunction_in_small_animals.Updated October 2013.Accessed May 9, 2018.